South Carolina Legislature Online
Official source for South Carolina legislation and controlled-substance law.
Open sourceNo. Psilocybin mushrooms are illegal statewide in South Carolina in 2026; no state or local reform has passed.
Federal law applies and no state-level reform has passed or is actively progressing as of the last-reviewed date. Ketamine is legal with a prescription; psilocybin, MDMA, DMT, ibogaine, and LSD remain Schedule I under both federal and state law. No regulated therapeutic program, statewide decriminalization, or city deprioritization resolution is in effect.
Official source for South Carolina legislation and controlled-substance law.
Open sourceAs of 2026, South Carolina does not have a licensed psilocybin access program. Legal options for residents include:
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No. Psilocybin mushrooms are illegal statewide in South Carolina in 2026; no state or local reform has passed.
No. Psilocybin mushrooms are Schedule I under both federal and South Carolina state law. No therapeutic-access program, statewide decriminalization, or city-level deprioritization resolution is in effect.
No. Psilocybin mushrooms are Schedule I under both federal law and South Carolina state law. No therapeutic-access program, statewide decriminalization, or city-level deprioritization resolution is in effect as of the last-reviewed date.
Ketamine is legal in South Carolina with a prescription, administered through licensed clinics. Psilocybin, MDMA, DMT, ibogaine, and LSD remain Schedule I under both federal and South Carolina state law, with no regulated therapeutic program, decriminalization, or city deprioritization resolution in effect.
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