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The Psychedelic Journal · Long-form analysis

Analysis

In-depth briefings on agency actions, clinical and preclinical research, and state and federal law and policy — with primary sources, scores, and clear limits on claims.

Neuroscience

Electrical Stimulation as Ketamine Alternative in Neurons

Study shows electrical stimulation mimics ketamine effects in neurons, suggesting potential non-drug therapies for depression.

Aug 01, 2026

Policy

DEA Seeks Comments on Form 222 Extension: Impact on Psychedelics

The DEA's extension of Form 222 maintains regulatory oversight of Schedules I and II substances, impacting psychedelic research and industry compliance.

Jul 23, 2026

Policy

EPA's Proposed SNURs: Impact on Psychedelic Chemical Substances

EPA's proposed SNURs under TSCA may affect the manufacturing and processing of chemicals relevant to psychedelic research, requiring 90-day pre-notification.

Jul 23, 2026

Policy

FDA's CMC Strategy for Accelerated Psychedelic Therapies

The FDA's strategy on CMC readiness could streamline psychedelic therapy development, addressing unmet medical needs faster.

Jul 23, 2026

Electrical Stimulation as Ketamine Alternative in Neurons

DEA Seeks Comments on Form 222 Extension: Impact on Psychedelics

EPA's Proposed SNURs: Impact on Psychedelic Chemical Substances

FDA's CMC Strategy for Accelerated Psychedelic Therapies

Psycholytic Therapy: Historical Insights for Modern Psychedelic Research

Virtual Reality's Role in Transformative Experiences

Advancing Treatment-Resistant Depression Research

Magnesium-Ibogaine in TBI Treatment: Emerging Insights

Ketamine Therapy for Grief-Related Depression: A New Frontier

FDA's Regulatory Framework for Psychedelics in the US

Psilocybin's Role in Epilepsy: Therapeutic Potential and Challenges

Psilocybin's Impact on Decision-Making in Uncertain Contexts

New Framework for Multi-Scale Disease Progression

Psychedelics in Treating Substance Use Disorders: Emerging Research

Lilly's $2.8B Psychedelic Investment: A New Era in Trials

Distinct Neural Mechanisms of Ketamine's Analgesic and Dissociative Effects

Psilocybin's Impact on Dendritic Signaling and Serotonin Receptors

Ibogaine's Potential in Ketamine Use Disorder Treatment

Understanding TRD: Multi-Pillar Approach in Neuroscience

New Framework for Treatment-Resistant Depression: Multi-Pillar Approach

Substance Trends in Drivers: Victoria, Australia Study

Ketamine's Antidepressant Effects: Role of CX3CL1/CX3CR1 Signaling

Hybrid Group Therapy Model for Psilocybin in Terminal Care

Distinct Neural Correlates of Ketamine Analgesia and Dissociation

EEG Complexity Drop in DMT Sessions: Implications for Research

EEG Complexity Dip in DMT Sessions: Implications for Research

Psilocybin Dose Measurement in Retreat Settings: New Insights

DMT Abort Tracker Enhances Cluster Headache Research

Psilocybin's Sex-Specific Effects in Schizophrenia Models

DMT Abort Tracker: Advancing Cluster Headache Research

Nigerian Medicinal Plants: Drug Discovery Prospects and Challenges

Psychedelic Research and Mysticism: Implications and Biases

Integrated PTSD and SUD Treatment for Adolescents: Evidence and Future

Visuomotor Mismatch EEG Responses: Implications for Clinical Trials

Visuomotor Mismatch EEG Responses: New Insights in Human Research

Combination Therapies in Parkinson's Research: New Avenues

Esketamine's Limited Impact on BDNF in TRD: Clinical Insights

Ketamine's Short-Term Efficacy for SUD: A Meta-Analysis Insight

FDA Fast-Tracks Psychedelic Research Following Executive Order

Spiritual Concerns in Psychedelic Therapy for Palliative Care

UK's Divergent Policies on Psychedelics and Assisted Suicide Drugs

Ketamine & Psychedelics in Depression: Current Evidence & Future Directions

Publication Bias in Psilocybin Depression Trials: Implications

Ketamine and Psychedelics in Depression Treatment: A Review

Phenomenology of Ruminations: Implications for Psychiatry

5-HT(2A)-TrkB Signaling in Psychedelic Effects: Implications

Ethical Considerations in Neurotechnology Development

Psilocybin's Impact on Neural Avalanches: New Insights

Psychedelic Therapies for PTSD: MDMA's Emerging Role

Speech Dynamics in Psilocybin Therapy for PTSD: New Insights

Ketamine Therapy Gains Traction in Iowa Amid Depression Treatment Challenges

FDA Guidance May Reshape Psychedelic Trials in the US

CLIA Regulations Update: Implications for Psychedelic Research

Medicare 2027 Policies: Implications for Psychedelic Therapies

FDA's New Psychedelic Trial Guidance: Impacts and Implications

Psilocybin's Role in Enhancing Brain Synaptic Plasticity

FDA Schedules Hearing on Psychedelics for Medical Use

Ketamine Therapy for Veterans Faces Funding Challenges

ANCHOR Framework's Role in Psychedelic-Assisted Therapy

White Matter Signals: New Insights in Brain Monitoring

Psychotropic Drug Monitoring in Bariatric Surgery Patients

cTBS Reduces Relapse in Alcohol Use Disorder: Clinical Trial Insights

Psilocybin and Synaptic Plasticity: Contextual Effects in Therapy

Sex-Dependent Effects of Psychedelics: Insights from Rodent Models

FDA's New Guidance on Psychedelic Trials: Implications and Risks

Neuroimaging Predictors of Ketamine Response in Treatment

FDA Finalizes Psychedelics Guidance, Easing Path to Approval

FDA Finalizes Psychedelic Trial Guidance: Impacts on Research

FDA Clarifies MDMA and Psilocybin Trial Guidelines

GABA+SSRIs Combo: Promising Depression Treatment in China

Selenium Nanoparticles Show Promise in Depression Treatment

Interprofessional Views on Psychiatric Polypharmacy Practices

PTSD Treatment Preferences: Psychedelics vs. Traditional Therapies

Challenges in Schizophrenia Drug Discovery: Animal Models Under Scrutiny

Zero Prediction Errors in Neural Processing and Psychedelics

DMT Immersion Study: Neuroscience Insights and Limits

Dietary Supplement Use for Mood in Poland: A Public Health Concern

Psilocybin's Dual Role: Therapy and Spirituality Explored

Psilocybin's Therapeutic and Spiritual Potential: A Scholarly Analysis

Ketamine Therapy at IMH: A New Hope for Depression in Singapore