Retreat directory

Find a legal psychedelic retreat

US-licensed psilocybin service centers (Oregon Measure 109 and Colorado Prop 122), plus the more medically-structured international operators for ayahuasca, ibogaine, and 5-MeO-DMT. Inclusion is not endorsement.

The Soul Quest lesson. The best-documented US fatality in the modern retreat era happened at a Florida ayahuasca/kambo retreat in 2018 and resulted in a $15 million verdict in 2024. The retreats with the best safety records are the ones that screen aggressively, have medical personnel on site, publish their protocols, and will turn people away. If any retreat operator will not tell you what they do when a participant has a medical emergency, walk away.

The Center Origin (Denver, CO)

PSILOCYBIN · USA (Colorado)

The first licensed psilocybin healing center in Colorado under Prop 122 / Natural Medicine Health Act; received license March 31, 2025 and conducted the state's first regulated psilocybin session on June 6, 2025.

Colorado Prop 122 / Natural Medicine Health Act (licensed healing center)

Psilocybin Healing Centers of Colorado

PSILOCYBIN · USA (Colorado)

Denver-based licensed healing center operated by the team behind My Denver Therapy. Every facilitator is a Clinical Facilitator — state-licensed under Prop 122 AND a licensed mental-health professional (LPC, LMFT, PMHNP) — which is a higher bar than the baseline facilitator credential.

Colorado Prop 122 / Natural Medicine Health Act (licensed healing center)

Synthesis Retreats

PSILOCYBIN · Netherlands (truffles)

Psilocybin-truffle retreat program in the Netherlands with clinical research collaborations (Imperial College, University Hospital Basel).

Netherlands — psilocybin-containing truffles (sclerotia) are legal under Dutch law.

Temple of the Way of Light

AYAHUASCA · Peru (Iquitos)

Shipibo-tradition ayahuasca retreat in the Peruvian Amazon with long operational history and formal medical screening.

Peru — ayahuasca has specific cultural-heritage recognition; DMT preparations used in traditional ceremony are broadly tolerated.

Beond Ibogaine

IBOGAINE · Mexico (Cancún)

Medically-supervised ibogaine treatment with cardiac pre-screen (EKG, electrolytes), continuous telemetry, magnesium/potassium loading, and on-site physicians. Among the most medically structured Mexico-based programs.

Mexico — ibogaine is not federally scheduled.

Ibogaine carries documented cardiac mortality risk; the quality of the cardiac screening and monitoring protocol matters more than any other feature of the retreat.

Ambio Life Sciences

IBOGAINE · Mexico (Tijuana)

Partner facility with the Stanford MISTIC trial and Texas IMPACT program; full cardiac-safety protocol; frequently works with veterans groups.

Mexico — ibogaine is not federally scheduled.

Published outcomes include VERITAS (Veterans Exploring Treatment with Psychedelics) cohort.

Tandava Retreats

5 MEO DMT · Mexico

One of the few 5-MeO-DMT retreat operators with an explicit screening protocol; uses synthetic 5-MeO-DMT rather than toad-derived secretion, addressing both conservation concerns and purity.

Mexico — 5-MeO-DMT is not federally scheduled.

Synthetic sourcing protects the Sonoran Desert toad (Incilius alvarius), which is threatened by over-harvesting for ceremonial use.

How to vet any retreat

  1. Medical screening. A credible operator requires an intake form covering cardiovascular history, medications (particularly SSRIs/SNRIs/MAOIs/lithium/tramadol), psychiatric history (especially psychosis and bipolar I), and current medical conditions. If the sign-up is purely credit-card and date, that's a flag.
  2. On-site medical capacity. For ibogaine specifically, this means an on-site physician, continuous cardiac telemetry during the session, an AED, and pre-loaded magnesium/potassium correction. For ayahuasca and 5-MeO-DMT, at minimum a licensed first responder on premises.
  3. Written safety protocol. What happens if someone has a seizure? A hypertensive emergency? A psychotic break? A credible operator answers these with specifics, not vibes.
  4. Screening out is a good sign. Operators who turn people away are protecting you. Operators who accept everyone are protecting their revenue.
  5. Avoid stacking medicines. The Soul Quest case involved ayahuasca and kambo in the same program. Multi-medicine retreats increase risk combinatorially; the published deaths and near-deaths cluster here.
  6. Integration included? A good retreat bundles or requires integration support after the session. If post-retreat support is an upsell, consider pairing with a psychedelic-integration therapist separately.
  7. Legal context. US Measure 109 / Prop 122 centers operate under state licensure — verify current license status on the Oregon Psilocybin Services or Colorado DORA websites. International centers operate under local law, which does not protect you if you re-enter the US with residual substances.

What this list does not include

Underground US ayahuasca circles, unlicensed psilocybin retreats, peyote ceremonies for non-Native participants, and kambo-centered retreats are excluded by policy. This is not a moral judgment on individual practices — it is a product decision about what is defensible to list on a YMYL medical-reference site. If you are considering any of these, the ayahuasca, peyote, and kambo guides contain the harm-reduction context you need.

Last reviewed: 2026-04-24. Tell us what's changed — corrections@mindmedicinelaw.com.