Plain-language guide to Massachusetts’s psilocybin, MDMA, and psychedelic laws — what’s legal, what isn’t, and what may change.
Question 4 (Massachusetts Natural Psychedelic Substances Initiative) failed at the November 2024 ballot (57-43).
The following cities in Massachusetts have passed resolutions directing local police to treat entheogenic plant and fungi enforcement as the lowest priority: Somerville, Cambridge, Northampton, Easthampton, Salem, Amherst, Provincetown.
As of 2026, Massachusetts does not have a licensed psilocybin access program. Legal options for residents include:
No. Massachusetts voters rejected Question 4 — the Natural Psychedelic Substances Initiative — in November 2024 by a 57-43 margin. Psilocybin remains Schedule I under Massachusetts General Laws c.94C §31. Seven cities (Somerville, Cambridge, Northampton, Easthampton, Salem, Amherst, Provincetown) have passed deprioritization resolutions, but these affect local police priorities only and do not make psilocybin legal.
Yes. Question 4 on the November 2024 ballot would have decriminalized personal use and possession of psilocybin, DMT, mescaline, and ibogaine for adults and created a regulatory framework for therapeutic access. Voters rejected it 57% to 43%.
Not legally. Cambridge has a city deprioritization resolution, but Boston does not. Massachusetts state law applies in both cities — psilocybin is Schedule I. Cambridge's resolution directs local police to treat entheogen enforcement as lowest priority; it is not a legal protection against state or federal charges.
Yes. A new ballot initiative could be filed for a future election cycle. Advocacy organizations are analyzing what changes to the ballot language might improve passage. A legislative approach (through the state legislature rather than ballot initiative) is also possible.