Five questions. We match your goals, medical considerations, and legal constraints against what each therapy's evidence base and access landscape actually supports in 2026.
No. This quiz is an educational orientation tool. It is not medical advice and it does not substitute for a consultation with a licensed clinician. If you are considering any psychedelic therapy — including ones that are legally accessible, like ketamine — a medical evaluation is the appropriate starting point.
Ibogaine has the clearest cardiac contraindication profile and should not be considered without a pre-screen EKG and cardiology consult. Ketamine, MDMA, and classical psychedelics all raise blood pressure acutely and are relatively contraindicated in uncontrolled hypertension or recent cardiovascular events. Discuss with a cardiologist before proceeding with any of these.
Yes, significantly. SSRIs (and SNRIs) reduce or block the effects of classical psychedelics like psilocybin, LSD, and ayahuasca because they act on the same 5-HT2A receptor system. MDMA additionally has serotonin-syndrome concerns with SSRIs. Ketamine, which acts on a different receptor system, is less affected by SSRI use. Any reputable facilitator or prescribing clinician will ask about your regimen.
Classical psychedelics (psilocybin, LSD, ayahuasca, 5-MeO-DMT) are contraindicated in people with a personal history of psychotic disorders, and caution is strongly advised with a first-degree family history of schizophrenia or bipolar I. Published research trials exclude these populations, so we have no safety data to offer. This quiz does not recommend classical psychedelics in these cases.
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