Plain-language guide to Colorado’s psilocybin, MDMA, and psychedelic laws — what’s legal, what isn’t, and what may change.
Natural Medicine Health Act (Prop 122, 2022). Psilocybin healing centers began licensing in 2024–2025; Division of Professions and Occupations supervises facilitators. DMT, mescaline, and ibogaine scheduled for 2026 advisory-board review for inclusion in the therapeutic program.
Personal use, possession, and gifting of psilocybin, psilocin, DMT, ibogaine, and mescaline (non-peyote) is decriminalized for adults 21+. MDMA and LSD are NOT included — those remain Schedule I under state law.
The following cities in Colorado have passed resolutions directing local police to treat entheogenic plant and fungi enforcement as the lowest priority: Denver.
Peyote explicitly excluded from the decriminalization statute in deference to NAC concerns. Psilocybin-containing edibles and gummies are not a separately licensed retail product category — the Prop 122 program covers psilocybin in a facilitator-supervised healing-center setting. Personal possession and home use of psilocybin mushrooms by adults 21+ is decriminalized under state law, meaning it is not a criminal offense — but federal Schedule I status still applies.
Colorado has a licensed access program. Natural Medicine Health Act (Prop 122, 2022). Psilocybin healing centers began licensing in 2024–2025; Division of Professions and Occupations supervises facilitators. DMT, mescaline, and ibogaine scheduled for 2026 advisory-board review for inclusion in the therapeutic program. For guidance on choosing a service center and preparing for a session, see the legal psilocybin booking checklist.
Yes, with important conditions. Colorado's Natural Medicine Health Act (Proposition 122, passed November 2022) decriminalized personal possession, use, and gifting of psilocybin mushrooms for adults 21 and older under state law. Licensed psilocybin healing centers began operating in 2025, providing facilitated access without a prescription or diagnosis. Retail sale (like cannabis dispensaries) is not permitted — access must occur at a licensed healing center with a trained facilitator.
No. Colorado's psilocybin program is not modeled on cannabis retail. You cannot walk into a store and buy psilocybin mushrooms. Access is through a licensed healing center, where a trained facilitator administers the session on-site. Denver and other Colorado cannabis dispensaries do not sell psilocybin.
Denver voters passed Measure 301 in May 2019 — making it the first US city to decriminalize psilocybin mushrooms for personal adult use. That predated Prop 122; the state law now supersedes and broadens Denver's city measure. Personal possession in Denver is decriminalized, and licensed healing centers are available in the Denver metro area.
Prop 122 decriminalizes psilocybin, psilocin, DMT, ibogaine, and mescaline (non-peyote derived) for adults 21+. MDMA and LSD are explicitly NOT included and remain Schedule I under Colorado law. Peyote is excluded from the Colorado statute in deference to Native American Church concerns.
As of 2026, facilitated psilocybin sessions at licensed Colorado healing centers typically range from $1,500 to $4,000, depending on the facilitator, session length, and preparation/integration included. Costs break down roughly as: preparation session(s) $200–$600, dosing session $800–$2,500, integration session(s) $200–$600. Health insurance does not cover these costs as of 2026.
A licensed Colorado healing center session typically includes three phases: (1) Preparation — one or more sessions with your facilitator covering intentions, health history, and expectations. (2) Dosing session — you consume psilocybin on-site under continuous supervision of a trained facilitator, lasting 4–6 hours. (3) Integration — a follow-up session to process the experience. You can choose the setting (clinical or nature-immersive), dose level, and facilitator. You cannot take any product home.
Similar but different. Both require on-site facilitation and do not permit retail home purchase. Key differences: Colorado's Prop 122 also decriminalized personal possession statewide (Oregon did not do this separately); Colorado includes DMT, ibogaine, and mescaline under its decrim provision (Oregon's Measure 109 is psilocybin-only); Colorado's healing centers began licensing in 2024–2025 while Oregon's service centers have operated since January 2023.